Information on previous seminars is provided below (NOTE we are missing many talks and this will be updated ASAP!!)
Season 13, episode 5
Season 13, episode 4
Season 13, episode 2
Season 13, episode 1
Season 12, episode 5
Season 12, episode 4
Season 12, episode 3
Season 12, episode 2
Season 12, episode 1
On Thursday June 2nd, Dr. Sanulli and Dr. Bernado and Dr. Sanulli spoke about chromatin conformations and dynamics and using NMR to understand Huntington’s disease, respectively.
On Thursday May 5th, Dr. Bondos and Dr. Blackledge spoke about the role of disorder in transcription factor and applying NMR to understand IDR conformational behavior, respectively.
On Thursday April 7th Dr. Schuler and Dr. García Quiroz spoke about using single-molecule spectroscopy to understand disordered proteins and phase separation in the context of skin formation, respectively.
On Thursday February 3rd, Dr. Cyert and Dr. Gladfelter spoke about how short linear motifs and regulate IDR-dependent molecular function and how bimolecular condensates can respond to temperature, respectively
On Thursday February 3rd, Dr. Jacobs and Dr. Banerjee spoke about using theory and simulations to understand and predict complex phase behavior and understand the physical basis for phase separation in the context of chromatin remodeling, respectively
On Thursday December 18th, Dr. Morgan and Dr. Berlow spoke about small-molecule targeting of IDRs and using NMR to understand IDR dynamics and molecular recognition, respectively.
On Thursday December 2nd, Dr. Fuxreiter and Dr. Jiang spoke about computational methods for inferring IDR sequence properties for phase separation and how phase separation influences human disease in the context of transcription, respectively
On Thursday November 18th, Dr. Hofmann and Dr. Riback spoke about using single-molecule spectroscopy to understand IDR modes of molecular interactions and how condensate composition can influence molecular function, respectively.
On Thursday November 4th, Dr. Fordyce and Dr. Musselman spoke about new high-throughput approaches to measure protein:protein and protein:DNA interactions and understanding disorder in the context of the nucleosome, respectively.
On Thursday Oct 21st Dr. Salvatella and Dr. Jarosz spoke about heterotypic buffering in phase separation and IDP-dependent inheritance, respectively.
On Thursday October 7th, Dr. Schuster and Dr. Khanna spoke about synthetic biology approaches for synthetic condensate design and biophysical dissection of TDP-43 in the context of RNA binding and phase separation, respectively.
On Thursday September 23rd, Dr. Knowles and Dr. Mittal spoke about the molecular kinetics of amyloid assembly and using computational models across multiple resolutions to understand disordered proteins, respectively.
On Thursday August 19th Dr. Soranno and Dr. Perry spoke about single-molecule spectroscopy to understand disordered linkers in IDRs and heterotypic buffering in phase separation and IDP-dependent inheritance, respectively.
On Thursday August 5th Dr. Beveridge and Dr. Castañeda spoke about using spectrometry to understand disordered proteins and the molecular basis for self-assembly of UBQLN2, respectively.
On Thursday July 22nd, Dr. Rosenzweig and Dr. Hondele spoke about how IDRs interact with chaperones and the role of IDRs in DEAD-box helicases, respectively.
On Thursday July 8th, Dr. Tosatto and Dr. Linse spoke about bioinformatic approaches to characterize and catalog disordered regions and how alpha-synuclein interacts with membranes, respectively.
On Thursday June 24th Dr. Collepardo and Dr. Chong spoke about chromatin organization and transcriptional regulation and dynamics, respectively.
On Thursday June 10th, Dr. Numata and Dr. Forman-Kay spoke about spider silk self-assembly and the biophysical basis for biomolecular self-assembly, respectively.
On Thursday May 27th, Dr. Hlouchová and Dr. Zweckstetter spoke about about the determinants of protein sequence evolution and biomolecular condensation of tau, respectively.
On Thursday May 13th, Dr. Berchowitz and Dr. Staller spoke about the role of RNA binding protein assemblies in function and the molecular basis for activation domain function, respectively.
On Thursday April 29th, Dr. Srivastava and Dr. Stott spoke about new methods for the simulation of disordered proteins and how disorder and spatial proximity regulates function contributes to enzyme function, respectively.
On Thursday April 15th, Dr. Si and Dr. Barbar spoek about protein-based information storage and how disorder and multivalency contributes to function in viruses and transcription, respectively.
On Thursday April 1st, Dr. Spruijt and Dr. Strader spoke about minimal peptide systems for condensate formation and how transcriptional regulation can be tuned by cytoplasmic condensates.
On Thursday March 4th Dr. Fitzpatrick and Dr. Showalter spoke about structural characterization of patient-derived amyloid assemblies and using carbon-detect NMR to examine post-translational modifications in IDRs, respectively.
On Thursday March 4th Dr. Jensen and Dr. Ivarsson spoke using NMR to examine residual structure and dynamics in signaling IDRs, while Dr. Ivarsson debut new high-throughput technologies for phage display-based IDR motif discovery, respectively.
On Thursday Feb 18th Dr. Lemke and Dr. Böke spoke about new tools for studying IDRs in cells and how IDRs contribute to biomolecular assembly in the balbiani body, respectively.
On Thursday Feb. 4th Dr. Dormann and Dr. Longhi spoke about post-translational modifications in neurodegeneration and phase separation, and biomolecular condensates in viral assembly, respectively.
On Thursday Jan 21st Dr. Alberti and Dr. Jemth spoke about IDRs as molecular tools for stress survival and the molecular biophysics of coupled folding and binding across evolution, respectively.
On Thursday Jan 7th Dr. Partch and Dr. Seydoux spoke about IDRs in timekeeping and IDRs in the context of biomolecular condensates respectively.
On Thursday Dec. 17th held our first (annual??) hold our IDPSIG/IDPSeminars Holiday Bash! Come for the science, stay for the festive cheer!
On Thursday Nov. 19th Dr. Sukenik and Dr. Zeno spoke about IDRs as sensors of intracellular state and IDRs in membrane curvature sensing, respectively
On Thursday December 3rd Dr. Jonikas and Dr. Šarić will speak about the pyrenoid assembly
On Thursday Nov. 5th Dr. Ball and Dr. Kriwacki will speak the physical basis for proline-rich IDR interactions with SH3 domains and the phase behavior of the nucleolus, respectively.
On Thursday Oct. 29th Dr. Elbaum-Garfinkle and Dr. Nott spoke about sequence-based tuning of complex coacervates and the determinants and modulation of bimolecular condensates, respectively.
On Thursday Oct. 15th Dr. Bolognesi and Dr. Shammas spoke about deep mutagenesis for studying IDR function and the role of IDRs in transcription factor function, respectively.
On Thursday Oct. 1st Dr. Chung and Dr. de Prat-Gay spoke about single-molecule fluorescence spectroscopy of binding and aggregation in disordered proteins and molten globule-driven phase separation in viral factory assembly, respectively.
On Thursday Sept 3rd Dr. Chilkoti and Dr. Kragelund spoke about rational design of artificial IDPs for tunable phase behavior and the interplay between membrane-proteins and disorder.
On Thursday Sept 3rd Dr. Lasker and Dr. Loog spoke about the complex sequence-to-function relationships in a phase separating bacterial protein and rational design of phospho-regulatory networks, respectively.
On Thursday August 20th Dr. Drummond and Dr. Cai spoke about novel ways to think about evolution in IDRs and the intersection of phase separation and transcriptional regulation.
On Thursday August 6th Dr. Heiðarsson and Dr. Hurley spoke about using single-molecule spectroscopy to understand IDPs and the role of disorder in circadian rhythm, respectively.
On Thursday July 23rd Dr. Rhoades and Dr. Theillet spoke about understanding IDPs involved in cellular dysfunction and new approaches to study phosphorylated IDPs, respectively
On Thursday July 9th Dr. Mukhopadhyay and Dr. Davey spoke about the dynamics of IDPs in liquid phase separation and how SLIMs encode function in disordered proteins, respectively.
On Thursday June 18th Dr. Mittag and Dr. Barran spoke about biophysical insights into the basis of liquid-liquid phase separation and applying mass spectrometry to obtain structural information on IDPs, respectively.
On Thursday June 4th Dr. Milles and Dr. Chemes spoek about studying IDPs using NMR and fluorescence spectroscopy, and how function is encoded into viral motifs in the E1A protein, respectively.
On Thursday May 21st Dr. Robustelli and Dr. Boothby spoke about using simulations to understand molecular recognition and the physical basis for stress tolerance in tardigrades, respectively.
On Thursday May 7th Dr. Arisio and Dr. Narlikar spoke about synthetic membraneless compartments and phase separation in chromatin, respectively.