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resources
Proteome-wide tools for disorder prediction
Published:
Here we include a non-exhaustive list of resources that may be useful for assessing if your favourite protein is disordered (or not). These resources are not predictors for an arbitrary sequence, but instead let you examine a naturally occurring protein to identify disordered regions.
talks
May 7th speakers: Paolo Arosio and Geeta Narlikar
Published:
On Thursday May 7th Dr. Arisio and Dr. Narlikar spoke about synthetic membraneless compartments and phase separation in chromatin, respectively.
May 21st speakers: Paul Robustelli and Thomas Boothby
Published:
On Thursday May 21st Dr. Robustelli and Dr. Boothby spoke about using simulations to understand molecular recognition and the physical basis for stress tolerance in tardigrades, respectively.
June 4th speakers: Sigrid Milles and Lucia Chemes
Published:
On Thursday June 4th Dr. Milles and Dr. Chemes spoek about studying IDPs using NMR and fluorescence spectroscopy, and how function is encoded into viral motifs in the E1A protein, respectively.
June 18th speakers: Tanja Mittag and Perdita Barran
Published:
On Thursday June 18th Dr. Mittag and Dr. Barran spoke about biophysical insights into the basis of liquid-liquid phase separation and applying mass spectrometry to obtain structural information on IDPs, respectively.
July 9th speakers: Samrat Mukhopadhyay and Norman Davey
Published:
On Thursday July 9th Dr. Mukhopadhyay and Dr. Davey spoke about the dynamics of IDPs in liquid phase separation and how SLIMs encode function in disordered proteins, respectively.
July 23rd speakers: Elizabeth Rhoades and François-Xavier Theillet
Published:
On Thursday July 23rd Dr. Rhoades and Dr. Theillet spoke about understanding IDPs involved in cellular dysfunction and new approaches to study phosphorylated IDPs, respectively
August 6th speakers: Petur Heidarsson and Jennifer Hurley
Published:
On Thursday August 6th Dr. Heiðarsson and Dr. Hurley spoke about using single-molecule spectroscopy to understand IDPs and the role of disorder in circadian rhythm, respectively.
August 20th speakers: Allan Drummond and Danfeng Cai
Published:
On Thursday August 20th Dr. Drummond and Dr. Cai spoke about novel ways to think about evolution in IDRs and the intersection of phase separation and transcriptional regulation.
Sept 3rd speakers: Keren Lasker and Mart Loog
Published:
On Thursday Sept 3rd Dr. Lasker and Dr. Loog spoke about the complex sequence-to-function relationships in a phase separating bacterial protein and rational design of phospho-regulatory networks, respectively.
Sept 17th speakers: Ashutosh Chilkoti and Birthe Kragelund
Published:
On Thursday Sept 3rd Dr. Chilkoti and Dr. Kragelund spoke about rational design of artificial IDPs for tunable phase behavior and the interplay between membrane-proteins and disorder.
Oct. 1st speakers: Hoi Sung Chung and Gonzalo Prat-Gay
Published:
On Thursday Oct. 1st Dr. Chung and Dr. de Prat-Gay spoke about single-molecule fluorescence spectroscopy of binding and aggregation in disordered proteins and molten globule-driven phase separation in viral factory assembly, respectively.
Oct. 15th speakers: Benedetta Bolognesi and Sarah Shammas
Published:
On Thursday Oct. 15th Dr. Bolognesi and Dr. Shammas spoke about deep mutagenesis for studying IDR function and the role of IDRs in transcription factor function, respectively.
Oct. 29th speakers: Shana Elbaum-Garfinke and Tim Nott
Published:
On Thursday Oct. 29th Dr. Elbaum-Garfinkle and Dr. Nott spoke about sequence-based tuning of complex coacervates and the determinants and modulation of bimolecular condensates, respectively.
Nov. 5th speakers: K. Aurelia Ball and Richard Kriwacki
Published:
On Thursday Nov. 5th Dr. Ball and Dr. Kriwacki will speak the physical basis for proline-rich IDR interactions with SH3 domains and the phase behavior of the nucleolus, respectively.
Dec. 3rd speakers: Martin Jonikas and Andela Šarić
Published:
On Thursday December 3rd Dr. Jonikas and Dr. Šarić will speak about the pyrenoid assembly
Nov. 19th speakers: Shahar Sukenik and Wade Zeno
Published:
On Thursday Nov. 19th Dr. Sukenik and Dr. Zeno spoke about IDRs as sensors of intracellular state and IDRs in membrane curvature sensing, respectively
Dec. 17th speakers: IDPSIG/IDPSeminars Holiday Bash
Published:
On Thursday Dec. 17th held our first (annual??) hold our IDPSIG/IDPSeminars Holiday Bash! Come for the science, stay for the festive cheer!
Jan. 7th speakers: Carrie Partch and Geraldine Seydoux
Published:
On Thursday Jan 7th Dr. Partch and Dr. Seydoux spoke about IDRs in timekeeping and IDRs in the context of biomolecular condensates respectively.
Jan. 21st speakers: Simon Alberti and Per Jemth
Published:
On Thursday Jan 21st Dr. Alberti and Dr. Jemth spoke about IDRs as molecular tools for stress survival and the molecular biophysics of coupled folding and binding across evolution, respectively.
Feb. 4th speakers: Dorothee Dormann and Sonia Longhi
Published:
On Thursday Feb. 4th Dr. Dormann and Dr. Longhi spoke about post-translational modifications in neurodegeneration and phase separation, and biomolecular condensates in viral assembly, respectively.
Feb. 18th speakers: Ed Lemke and Elvan Böke
Published:
On Thursday Feb 18th Dr. Lemke and Dr. Böke spoke about new tools for studying IDRs in cells and how IDRs contribute to biomolecular assembly in the balbiani body, respectively.
Mar. 4th speakers: Marlene Ringkjøbing Jensen and Ylva Ivarsson
Published:
On Thursday March 4th Dr. Jensen and Dr. Ivarsson spoke using NMR to examine residual structure and dynamics in signaling IDRs, while Dr. Ivarsson debut new high-throughput technologies for phage display-based IDR motif discovery, respectively.
Mar. 18th speakers: Anthony Fitzpatrick and Scott Showalter
Published:
On Thursday March 4th Dr. Fitzpatrick and Dr. Showalter spoke about structural characterization of patient-derived amyloid assemblies and using carbon-detect NMR to examine post-translational modifications in IDRs, respectively.
Apr. 1st speakers: Evan Spruijt and Lucia Strader
Published:
On Thursday April 1st, Dr. Spruijt and Dr. Strader spoke about minimal peptide systems for condensate formation and how transcriptional regulation can be tuned by cytoplasmic condensates.
Apr. 15th speakers: Kausik Si and Elisar Barbar
Published:
On Thursday April 15th, Dr. Si and Dr. Barbar spoek about protein-based information storage and how disorder and multivalency contributes to function in viruses and transcription, respectively.
Apr. 29th speakers: Anand Srivastava and Katherine Stott
Published:
On Thursday April 29th, Dr. Srivastava and Dr. Stott spoke about new methods for the simulation of disordered proteins and how disorder and spatial proximity regulates function contributes to enzyme function, respectively.
May 13th speakers: Luke Berchowitz and Max Staller
Published:
On Thursday May 13th, Dr. Berchowitz and Dr. Staller spoke about the role of RNA binding protein assemblies in function and the molecular basis for activation domain function, respectively.
May 27th speakers: Klára Hlouchová and Markus Zweckstetter
Published:
On Thursday May 27th, Dr. Hlouchová and Dr. Zweckstetter spoke about about the determinants of protein sequence evolution and biomolecular condensation of tau, respectively.
Jun. 10th speakers: Keiji Numata and Julie Forman-Kay
Published:
On Thursday June 10th, Dr. Numata and Dr. Forman-Kay spoke about spider silk self-assembly and the biophysical basis for biomolecular self-assembly, respectively.
Jun. 24th speakers: Rosana Collepardo and Shasha Chong
Published:
On Thursday June 24th Dr. Collepardo and Dr. Chong spoke about chromatin organization and transcriptional regulation and dynamics, respectively.
July. 8th speakers: Silvio Tosatto and Sara Linse
Published:
On Thursday July 8th, Dr. Tosatto and Dr. Linse spoke about bioinformatic approaches to characterize and catalog disordered regions and how alpha-synuclein interacts with membranes, respectively.
July. 22nd speakers: Rina Rosenzweig and Maria Hondele
Published:
On Thursday July 22nd, Dr. Rosenzweig and Dr. Hondele spoke about how IDRs interact with chaperones and the role of IDRs in DEAD-box helicases, respectively.
August. 5th speakers: Rebecca Beveridge and Carlos A. Castañeda
Published:
On Thursday August 5th Dr. Beveridge and Dr. Castañeda spoke about using spectrometry to understand disordered proteins and the molecular basis for self-assembly of UBQLN2, respectively.
August. 19th speakers: Andrea Soranno and Sarah Perry
Published:
On Thursday August 19th Dr. Soranno and Dr. Perry spoke about single-molecule spectroscopy to understand disordered linkers in IDRs and heterotypic buffering in phase separation and IDP-dependent inheritance, respectively.
September 23rd speakers: Tuomas Knowles and Jeetain Mittal
Published:
On Thursday September 23rd, Dr. Knowles and Dr. Mittal spoke about the molecular kinetics of amyloid assembly and using computational models across multiple resolutions to understand disordered proteins, respectively.
October 7th speakers: Ben Schuster and May Khanna
Published:
On Thursday October 7th, Dr. Schuster and Dr. Khanna spoke about synthetic biology approaches for synthetic condensate design and biophysical dissection of TDP-43 in the context of RNA binding and phase separation, respectively.
Oct. 21s speakers: Xavier Salvatella and Dan Jarosz
Published:
On Thursday Oct 21st Dr. Salvatella and Dr. Jarosz spoke about heterotypic buffering in phase separation and IDP-dependent inheritance, respectively.
November 4th speakers: Polly Fordyce and Catherine Musselman
Published:
On Thursday November 4th, Dr. Fordyce and Dr. Musselman spoke about new high-throughput approaches to measure protein:protein and protein:DNA interactions and understanding disorder in the context of the nucleosome, respectively.
November 18th speakers: Hagen Hofmann and Josh Riback
Published:
On Thursday November 18th, Dr. Hofmann and Dr. Riback spoke about using single-molecule spectroscopy to understand IDR modes of molecular interactions and how condensate composition can influence molecular function, respectively.
December 2nd speakers: Monika Fuxreiter and Hao Jiang
Published:
On Thursday December 2nd, Dr. Fuxreiter and Dr. Jiang spoke about computational methods for inferring IDR sequence properties for phase separation and how phase separation influences human disease in the context of transcription, respectively
December 18th speakers: Brittany Morgan and Rebecca Berlow
Published:
On Thursday December 18th, Dr. Morgan and Dr. Berlow spoke about small-molecule targeting of IDRs and using NMR to understand IDR dynamics and molecular recognition, respectively.
February 3rd speakers: Will Jacobs and Priya Banerjee
Published:
On Thursday February 3rd, Dr. Jacobs and Dr. Banerjee spoke about using theory and simulations to understand and predict complex phase behavior and understand the physical basis for phase separation in the context of chromatin remodeling, respectively
March 3rd speakers: Martha Cyert and Amy Gladfelter
Published:
On Thursday February 3rd, Dr. Cyert and Dr. Gladfelter spoke about how short linear motifs and regulate IDR-dependent molecular function and how bimolecular condensates can respond to temperature, respectively
April. 7th speakers: Ben Schuler and Felipe García Quiroz
Published:
On Thursday April 7th Dr. Schuler and Dr. García Quiroz spoke about using single-molecule spectroscopy to understand disordered proteins and phase separation in the context of skin formation, respectively.
upcoming-talks
May. 5th speakers: Sarah Bondos and Martin Blackledge
Published:
On Thursday May 5th, Dr. Bondos and Dr. Blackledge will speak about topics the role of disorder in transcription factor and applying NMR to understand IDR conformational behavior, respectively.
June. 2nd speakers: Hyun Kate Lee and Serena Sanulli
Published:
On Thursday June 2nd, Dr. Lee and Dr. Sanulli will speak about topics TBD.