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resources
Proteome-wide tools for disorder prediction
Published:
Here we include a non-exhaustive list of resources that may be useful for assessing if your favourite protein is disordered (or not). These resources are not predictors for an arbitrary sequence, but instead let you examine a naturally occurring protein to identify disordered regions.
talks
May 7th speakers: Paolo Arosio and Geeta Narlikar
Published:
On Thursday May 7th Dr. Arisio and Dr. Narlikar spoke about synthetic membraneless compartments and phase separation in chromatin, respectively.
May 21st speakers: Paul Robustelli and Thomas Boothby
Published:
On Thursday May 21st Dr. Robustelli and Dr. Boothby spoke about using simulations to understand molecular recognition and the physical basis for stress tolerance in tardigrades, respectively.
June 4th speakers: Sigrid Milles and Lucia Chemes
Published:
On Thursday June 4th Dr. Milles and Dr. Chemes spoek about studying IDPs using NMR and fluorescence spectroscopy, and how function is encoded into viral motifs in the E1A protein, respectively.
June 18th speakers: Tanja Mittag and Perdita Barran
Published:
On Thursday June 18th Dr. Mittag and Dr. Barran spoke about biophysical insights into the basis of liquid-liquid phase separation and applying mass spectrometry to obtain structural information on IDPs, respectively.
July 9th speakers: Samrat Mukhopadhyay and Norman Davey
Published:
On Thursday July 9th Dr. Mukhopadhyay and Dr. Davey spoke about the dynamics of IDPs in liquid phase separation and how SLIMs encode function in disordered proteins, respectively.
July 23rd speakers: Elizabeth Rhoades and François-Xavier Theillet
Published:
On Thursday July 23rd Dr. Rhoades and Dr. Theillet spoke about understanding IDPs involved in cellular dysfunction and new approaches to study phosphorylated IDPs, respectively
August 6th speakers: Petur Heidarsson and Jennifer Hurley
Published:
On Thursday August 6th Dr. Heiðarsson and Dr. Hurley spoke about using single-molecule spectroscopy to understand IDPs and the role of disorder in circadian rhythm, respectively.
August 20th speakers: Allan Drummond and Danfeng Cai
Published:
On Thursday August 20th Dr. Drummond and Dr. Cai spoke about novel ways to think about evolution in IDRs and the intersection of phase separation and transcriptional regulation.
Sept 3rd speakers: Keren Lasker and Mart Loog
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On Thursday Sept 3rd Dr. Lasker and Dr. Loog spoke about the complex sequence-to-function relationships in a phase separating bacterial protein and rational design of phospho-regulatory networks, respectively.
Sept 17th speakers: Ashutosh Chilkoti and Birthe Kragelund
Published:
On Thursday Sept 3rd Dr. Chilkoti and Dr. Kragelund spoke about rational design of artificial IDPs for tunable phase behavior and the interplay between membrane-proteins and disorder.
Oct. 1st speakers: Hoi Sung Chung and Gonzalo Prat-Gay
Published:
On Thursday Oct. 1st Dr. Chung and Dr. de Prat-Gay spoke about single-molecule fluorescence spectroscopy of binding and aggregation in disordered proteins and molten globule-driven phase separation in viral factory assembly, respectively.
Oct. 15th speakers: Benedetta Bolognesi and Sarah Shammas
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On Thursday Oct. 15th Dr. Bolognesi and Dr. Shammas spoke about deep mutagenesis for studying IDR function and the role of IDRs in transcription factor function, respectively.
Oct. 29th speakers: Shana Elbaum-Garfinke and Tim Nott
Published:
On Thursday Oct. 29th Dr. Elbaum-Garfinkle and Dr. Nott spoke about sequence-based tuning of complex coacervates and the determinants and modulation of bimolecular condensates, respectively.