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Here we include a non-exhaustive list of resources that may be useful for assessing if your favourite protein is disordered (or not). These resources are not predictors for an arbitrary sequence, but instead let you examine a naturally occurring protein to identify disordered regions.
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On Thursday May 7th Dr. Arisio and Dr. Narlikar spoke about synthetic membraneless compartments and phase separation in chromatin, respectively.
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On Thursday May 21st Dr. Robustelli and Dr. Boothby spoke about using simulations to understand molecular recognition and the physical basis for stress tolerance in tardigrades, respectively.
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On Thursday June 4th Dr. Milles and Dr. Chemes spoek about studying IDPs using NMR and fluorescence spectroscopy, and how function is encoded into viral motifs in the E1A protein, respectively.
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On Thursday June 18th Dr. Mittag and Dr. Barran spoke about biophysical insights into the basis of liquid-liquid phase separation and applying mass spectrometry to obtain structural information on IDPs, respectively.
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On Thursday July 9th Dr. Mukhopadhyay and Dr. Davey spoke about the dynamics of IDPs in liquid phase separation and how SLIMs encode function in disordered proteins, respectively.
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On Thursday July 23rd Dr. Rhoades and Dr. Theillet spoke about understanding IDPs involved in cellular dysfunction and new approaches to study phosphorylated IDPs, respectively
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On Thursday August 6th Dr. Heiðarsson and Dr. Hurley spoke about using single-molecule spectroscopy to understand IDPs and the role of disorder in circadian rhythm, respectively.
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On Thursday August 20th Dr. Drummond and Dr. Cai spoke about novel ways to think about evolution in IDRs and the intersection of phase separation and transcriptional regulation.
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On Thursday Sept 3rd Dr. Lasker and Dr. Loog spoke about the complex sequence-to-function relationships in a phase separating bacterial protein and rational design of phospho-regulatory networks, respectively.
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On Thursday Sept 3rd Dr. Chilkoti and Dr. Kragelund spoke about rational design of artificial IDPs for tunable phase behavior and the interplay between membrane-proteins and disorder.
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On Thursday Oct. 1st Dr. Chung and Dr. de Prat-Gay spoke about single-molecule fluorescence spectroscopy of binding and aggregation in disordered proteins and molten globule-driven phase separation in viral factory assembly, respectively.
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On Thursday Oct. 15th Dr. Bolognesi and Dr. Shammas spoke about deep mutagenesis for studying IDR function and the role of IDRs in transcription factor function, respectively.
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On Thursday Oct. 29th Dr. Elbaum-Garfinkle and Dr. Nott spoke about sequence-based tuning of complex coacervates and the determinants and modulation of bimolecular condensates, respectively.
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On Thursday Nov. 5th Dr. Ball and Dr. Kriwacki will speak the physical basis for proline-rich IDR interactions with SH3 domains and the phase behavior of the nucleolus, respectively.
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On Thursday December 3rd Dr. Jonikas and Dr. Šarić will speak about the pyrenoid assembly
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On Thursday Nov. 19th Dr. Sukenik and Dr. Zeno spoke about IDRs as sensors of intracellular state and IDRs in membrane curvature sensing, respectively
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On Thursday Dec. 17th held our first (annual??) hold our IDPSIG/IDPSeminars Holiday Bash! Come for the science, stay for the festive cheer!
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On Thursday Jan 7th Dr. Partch and Dr. Seydoux spoke about IDRs in timekeeping and IDRs in the context of biomolecular condensates respectively.
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On Thursday Jan 21st Dr. Alberti and Dr. Jemth spoke about IDRs as molecular tools for stress survival and the molecular biophysics of coupled folding and binding across evolution, respectively.
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On Thursday Feb. 4th Dr. Dormann and Dr. Longhi spoke about post-translational modifications in neurodegeneration and phase separation, and biomolecular condensates in viral assembly, respectively.
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On Thursday Feb 18th Dr. Lemke and Dr. Böke spoke about new tools for studying IDRs in cells and how IDRs contribute to biomolecular assembly in the balbiani body, respectively.
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On Thursday March 4th Dr. Jensen and Dr. Ivarsson spoke using NMR to examine residual structure and dynamics in signaling IDRs, while Dr. Ivarsson debut new high-throughput technologies for phage display-based IDR motif discovery, respectively.
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On Thursday March 4th Dr. Fitzpatrick and Dr. Showalter spoke about structural characterization of patient-derived amyloid assemblies and using carbon-detect NMR to examine post-translational modifications in IDRs, respectively.
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On Thursday April 15th, Dr. Si and Dr. Barbar will speak about protein-based information storage and how disorder and multivalency contributes to function in viruses and transcription, respectively.
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On Thursday April 29th, Dr. Srivastava and Dr. Stott will speak about new methods for the simulation of disordered proteins and how disorder and spatial proximity regulates function contributes to enzyme function, respectively.